Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Schizophrenia)
rsID	Risk allele	Effect size
rs2007044	G	0.092
rs4129585	A	0.083
rs4391122	G	0.081
rs75968099	T	0.082
rs8042374	A	0.089
rs13240464	T	0.080
rs7893279	T	0.118
rs1378559	T	0.086
rs11693094	C	0.074
rs12129573	A	0.075
rs12826178	G	0.167
rs55661361	G	0.077
rs950169	C	0.080
rs72934570	C	0.136
rs36068923	G	0.084
rs17194490	T	0.096
rs2514218	C	0.076
rs75059851	A	0.087
rs2535627	T	0.069
rs12691307	A	0.070
rs7432375	G	0.069
rs111294930	A	0.090
rs12704290	G	0.101
rs140505938	T	0.090
rs4648845	T	0.070
rs10520163	T	0.063
rs4766428	T	0.066
rs117074560	C	0.164
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Schizophrenia)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.057	0.004	0.000	0.056	0.057
SOUTH	83	0.057	0.004	0.000	0.056	0.058
EAST	146	0.058	0.005	0.000	0.057	0.058
Populations
IBS	107	0.057	0.005	0.000	0.056	0.058
PIR	397	0.057	0.005	0.000	0.057	0.057

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Schizophrenia)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.501	ns	1	ns
IBS	WEST	107	168	0.998	ns	1	ns
IBS	SOUTH	107	83	0.859	ns	1	ns
IBS	EAST	107	146	0.148	ns	1	ns
WEST	SOUTH	168	83	0.848	ns	1	ns
WEST	EAST	168	146	0.104	ns	1	ns
SOUTH	EAST	83	146	0.250	ns	1	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Schizophrenia)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	−1.760	0.078	.	white	−1.720	0.085	.	white	−1.760	0.078	.	white	−0.690	0.490	.	white
pct75.95	0.180	0.857	.	white	0.900	0.368	.	white	0.180	0.857	.	white	1.570	0.116	.	white
pct50.75	1.380	0.168	.	white	−0.080	0.936	.	white	1.380	0.168	.	white	0.660	0.509	.	white
pct25.50	0.200	0.841	.	white	0.820	0.412	.	white	0.200	0.841	.	white	−1.150	0.250	.	white
pct25	−0.800	0.424	.	white	−0.670	0.503	.	white	−0.800	0.424	.	white	−0.600	0.549	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference