Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Sclerosing_cholangitis_and_ulcerative_colitis_combined)
rsID Risk allele Effect size
rs4676410 A 0.322
rs1452787 A 0.285
Effect size: LN(OR)
Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Sclerosing_cholangitis_and_ulcerative_colitis_combined)
count mean sd se lower.ci upper.ci
Pyrenean regions
WEST 168 0.120 0.055 0.004 0.112 0.128
SOUTH 83 0.140 0.064 0.007 0.126 0.154
EAST 146 0.137 0.059 0.005 0.127 0.146
Populations
IBS 107 0.131 0.060 0.006 0.120 0.143
PIR 397 0.130 0.059 0.003 0.124 0.136
Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Sclerosing_cholangitis_and_ulcerative_colitis_combined)
group1 group2 n1 n2 p p.signif p.adj p.adj.signif
IBS PIR 107 397 0.8680 ns 1.000 ns
IBS WEST 107 168 0.1240 ns 1.000 ns
IBS SOUTH 107 83 0.3310 ns 1.000 ns
IBS EAST 107 146 0.4850 ns 1.000 ns
WEST SOUTH 168 83 0.0134 * 0.134 ns
WEST EAST 168 146 0.0138 * 0.138 ns
SOUTH EAST 83 146 0.6980 ns 1.000 ns
* p < .05, ** p < .01, *** p < .001
Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Sclerosing_cholangitis_and_ulcerative_colitis_combined)
Percentile rank PIR WEST SOUTH EAST
adj.std.val p.value sig.val adj.std.val p.value sig.val adj.std.val p.value sig.val adj.std.val p.value sig.val
pct95 −0.040 0.968 . white −2.520 0.012 * −0.040 0.968 . white −0.130 0.897 . white
pct75.95 1.550 0.121 . white 0.270 0.787 . white 1.550 0.121 . white 0.660 0.509 . white
pct50.75 −0.100 0.920 . white −1.200 0.230 . white −0.100 0.920 . white 0.170 0.865 . white
pct25.50 −0.490 0.624 . white −0.260 0.795 . white −0.490 0.624 . white −0.370 0.711 . white
pct25 −0.560 0.575 . white 1.550 0.121 . white −0.560 0.575 . white −0.150 0.881 . white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference