Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Sporadic_neuroblastoma)
rsID	Risk allele	Effect size
rs2168101	C	0.351
rs72990858	G	0.528
rs3796727	A	0.262
rs6441201	A	0.207
rs17065417	C	0.357
rs35850753	T	0.666
rs10742682	T	0.215
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Sporadic_neuroblastoma)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.153	0.030	0.002	0.149	0.158
SOUTH	83	0.145	0.030	0.003	0.139	0.152
EAST	146	0.150	0.027	0.002	0.146	0.155
Populations
IBS	107	0.148	0.036	0.003	0.142	0.155
PIR	397	0.151	0.029	0.001	0.148	0.154

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Sporadic_neuroblastoma)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.5160	ns	1.000	ns
IBS	WEST	107	168	0.1960	ns	1.000	ns
IBS	SOUTH	107	83	0.4900	ns	1.000	ns
IBS	EAST	107	146	0.6060	ns	1.000	ns
WEST	SOUTH	168	83	0.0519	ns	0.519	ns
WEST	EAST	168	146	0.4040	ns	1.000	ns
SOUTH	EAST	83	146	0.2260	ns	1.000	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Sporadic_neuroblastoma)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	−0.640	0.522	.	white	−0.090	0.928	.	white	−0.640	0.522	.	white	−0.040	0.968	.	white
pct75.95	−0.890	0.373	.	white	−0.380	0.704	.	white	−0.890	0.373	.	white	−1.830	0.067	.	white
pct50.75	−0.110	0.912	.	white	2.250	0.024	*		−0.110	0.912	.	white	1.730	0.084	.	white
pct25.50	2.200	0.028	*		0.000	1.000	.	white	2.200	0.028	*		1.430	0.153	.	white
pct25	−0.930	0.352	.	white	−1.850	0.064	.	white	−0.930	0.352	.	white	−1.410	0.159	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference