Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Sporadic_neuroblastoma)
rsID Risk allele Effect size
rs2168101 C 0.351
rs72990858 G 0.528
rs3796727 A 0.262
rs6441201 A 0.207
rs17065417 C 0.357
rs35850753 T 0.666
rs10742682 T 0.215
Effect size: LN(OR)
Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Sporadic_neuroblastoma)
count mean sd se lower.ci upper.ci
Pyrenean regions
WEST 168 0.153 0.030 0.002 0.149 0.158
SOUTH 83 0.145 0.030 0.003 0.139 0.152
EAST 146 0.150 0.027 0.002 0.146 0.155
Populations
IBS 107 0.148 0.036 0.003 0.142 0.155
PIR 397 0.151 0.029 0.001 0.148 0.154
Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Sporadic_neuroblastoma)
group1 group2 n1 n2 p p.signif p.adj p.adj.signif
IBS PIR 107 397 0.5160 ns 1.000 ns
IBS WEST 107 168 0.1960 ns 1.000 ns
IBS SOUTH 107 83 0.4900 ns 1.000 ns
IBS EAST 107 146 0.6060 ns 1.000 ns
WEST SOUTH 168 83 0.0519 ns 0.519 ns
WEST EAST 168 146 0.4040 ns 1.000 ns
SOUTH EAST 83 146 0.2260 ns 1.000 ns
* p < .05, ** p < .01, *** p < .001
Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Sporadic_neuroblastoma)
Percentile rank PIR WEST SOUTH EAST
adj.std.val p.value sig.val adj.std.val p.value sig.val adj.std.val p.value sig.val adj.std.val p.value sig.val
pct95 −0.640 0.522 . white −0.090 0.928 . white −0.640 0.522 . white −0.040 0.968 . white
pct75.95 −0.890 0.373 . white −0.380 0.704 . white −0.890 0.373 . white −1.830 0.067 . white
pct50.75 −0.110 0.912 . white 2.250 0.024 * −0.110 0.912 . white 1.730 0.084 . white
pct25.50 2.200 0.028 * 0.000 1.000 . white 2.200 0.028 * 1.430 0.153 . white
pct25 −0.930 0.352 . white −1.850 0.064 . white −0.930 0.352 . white −1.410 0.159 . white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference