Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Stroke)
rsID	Risk allele	Effect size
rs16851055	G	0.113
rs2107595	A	0.113
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Stroke)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.053	0.021	0.002	0.050	0.056
SOUTH	83	0.060	0.021	0.002	0.055	0.064
EAST	146	0.051	0.023	0.002	0.048	0.055
Populations
IBS	107	0.054	0.022	0.002	0.050	0.058
PIR	397	0.054	0.022	0.001	0.051	0.056

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Stroke)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.93100	ns	1.0000	ns
IBS	WEST	107	168	0.69500	ns	1.0000	ns
IBS	SOUTH	107	83	0.07420	ns	0.7420	ns
IBS	EAST	107	146	0.35200	ns	1.0000	ns
WEST	SOUTH	168	83	0.02110	*	0.2110	ns
WEST	EAST	168	146	0.53700	ns	1.0000	ns
SOUTH	EAST	83	146	0.00583	**	0.0583	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Stroke)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	−0.170	0.865	.	white	−0.980	0.327	.	white	−0.170	0.865	.	white	−0.390	0.697	.	white
pct75.95	1.780	0.075	.	white	0.720	0.472	.	white	1.780	0.075	.	white	−0.070	0.944	.	white
pct50.75	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white
pct25.50	0.110	0.912	.	white	−1.040	0.298	.	white	0.110	0.912	.	white	−0.780	0.435	.	white
pct25	−1.750	0.080	.	white	0.850	0.395	.	white	−1.750	0.080	.	white	1.040	0.298	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference