Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Survival_in_breast_cancer)
rsID	Risk allele	Effect size
rs8113308	C	0.525
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Survival_in_breast_cancer)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	103	0.069	0.116	0.011	0.046	0.091
SOUTH	45	0.088	0.125	0.019	0.050	0.125
EAST	57	0.069	0.127	0.017	0.035	0.103
Populations
IBS	53	0.084	0.134	0.018	0.047	0.121
PIR	205	0.073	0.121	0.008	0.056	0.090

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Survival_in_breast_cancer)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	53	205	0.553	ns	1	ns
IBS	WEST	53	103	0.458	ns	1	ns
IBS	SOUTH	53	45	0.894	ns	1	ns
IBS	EAST	53	57	0.518	ns	1	ns
WEST	SOUTH	103	45	0.394	ns	1	ns
WEST	EAST	103	57	0.989	ns	1	ns
SOUTH	EAST	45	57	0.451	ns	1	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Survival_in_breast_cancer)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	−0.930	0.352	.	white	−1.400	0.162	.	white	−0.930	0.352	.	white	−0.050	0.960	.	white
pct75.95	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white
pct50.75	0.540	0.589	.	white	−0.280	0.779	.	white	0.540	0.589	.	white	−0.660	0.509	.	white
pct25.50	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white
pct25	−0.330	0.741	.	white	0.530	0.596	.	white	−0.330	0.741	.	white	0.660	0.509	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference