Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Systemic_sclerosis)
rsID	Risk allele	Effect size
rs6457617	T	0.476
rs3130573	G	0.223
rs2233287	A	0.270
rs10488631	C	0.300
rs13021401	T	0.191
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Systemic_sclerosis)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.077	0.042	0.003	0.071	0.083
SOUTH	83	0.079	0.043	0.005	0.070	0.089
EAST	146	0.074	0.041	0.003	0.067	0.080
Populations
IBS	107	0.080	0.042	0.004	0.072	0.088
PIR	397	0.076	0.042	0.002	0.072	0.080

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Systemic_sclerosis)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.376	ns	1	ns
IBS	WEST	107	168	0.528	ns	1	ns
IBS	SOUTH	107	83	0.873	ns	1	ns
IBS	EAST	107	146	0.212	ns	1	ns
WEST	SOUTH	168	83	0.684	ns	1	ns
WEST	EAST	168	146	0.474	ns	1	ns
SOUTH	EAST	83	146	0.324	ns	1	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Systemic_sclerosis)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	0.750	0.453	.	white	−0.200	0.841	.	white	0.750	0.453	.	white	0.290	0.772	.	white
pct75.95	−1.060	0.289	.	white	−1.570	0.116	.	white	−1.060	0.289	.	white	−2.510	0.012	*
pct50.75	0.550	0.582	.	white	0.240	0.810	.	white	0.550	0.582	.	white	0.180	0.857	.	white
pct25.50	−2.310	0.021	*		0.630	0.529	.	white	−2.310	0.021	*		0.640	0.522	.	white
pct25	1.870	0.061	.	white	0.720	0.472	.	white	1.870	0.061	.	white	1.270	0.204	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference