Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Taxane-induced_peripheral_neuropathy_in_breast_cancer)
rsID Risk allele Effect size
rs910920 A 0.562
Effect size: LN(OR)
Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Taxane-induced_peripheral_neuropathy_in_breast_cancer)
count mean sd se lower.ci upper.ci
Pyrenean regions
WEST 103 0.161 0.179 0.018 0.126 0.196
SOUTH 45 0.119 0.153 0.023 0.073 0.164
EAST 57 0.133 0.160 0.021 0.091 0.176
Populations
IBS 53 0.133 0.152 0.021 0.091 0.174
PIR 205 0.144 0.168 0.012 0.121 0.167
Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Taxane-induced_peripheral_neuropathy_in_breast_cancer)
group1 group2 n1 n2 p p.signif p.adj p.adj.signif
IBS PIR 53 205 0.658 ns 1 ns
IBS WEST 53 103 0.313 ns 1 ns
IBS SOUTH 53 45 0.681 ns 1 ns
IBS EAST 53 57 0.986 ns 1 ns
WEST SOUTH 103 45 0.156 ns 1 ns
WEST EAST 103 57 0.311 ns 1 ns
SOUTH EAST 45 57 0.663 ns 1 ns
* p < .05, ** p < .01, *** p < .001
Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Taxane-induced_peripheral_neuropathy_in_breast_cancer)
Percentile rank PIR WEST SOUTH EAST
adj.std.val p.value sig.val adj.std.val p.value sig.val adj.std.val p.value sig.val adj.std.val p.value sig.val
pct95 0.120 0.904 . white 1.490 0.136 . white 0.120 0.904 . white 0.520 0.603 . white
pct75.95 0.000 1.000 . white 0.000 1.000 . white 0.000 1.000 . white 0.000 1.000 . white
pct50.75 −0.560 0.575 . white −0.200 0.841 . white −0.560 0.575 . white −0.320 0.749 . white
pct25.50 0.000 1.000 . white 0.000 1.000 . white 0.000 1.000 . white 0.000 1.000 . white
pct25 0.530 0.596 . white −0.500 0.617 . white 0.530 0.596 . white 0.150 0.881 . white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference