Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Testicular_germ_cell_cancer)
rsID	Risk allele	Effect size
rs210138	G	0.365
rs4635969	A	0.329
rs2900333	C	0.278
rs2720460	A	0.215
rs2839186	T	0.231
rs10510452	A	0.215
rs3805663	A	0.223
rs3790672	C	0.182
rs2072499	G	0.174
rs7010162	C	0.199
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Testicular_germ_cell_cancer)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	65	0.109	0.024	0.003	0.103	0.115
SOUTH	38	0.109	0.030	0.005	0.099	0.118
EAST	89	0.112	0.025	0.003	0.107	0.117
Populations
IBS	54	0.110	0.026	0.004	0.103	0.117
PIR	192	0.110	0.026	0.002	0.107	0.114

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Testicular_germ_cell_cancer)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	54	192	0.913	ns	1	ns
IBS	WEST	54	65	0.828	ns	1	ns
IBS	SOUTH	54	38	0.804	ns	1	ns
IBS	EAST	54	89	0.609	ns	1	ns
WEST	SOUTH	65	38	0.951	ns	1	ns
WEST	EAST	65	89	0.432	ns	1	ns
SOUTH	EAST	38	89	0.468	ns	1	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Testicular_germ_cell_cancer)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	1.300	0.194	.	white	−0.190	0.849	.	white	1.300	0.194	.	white	0.510	0.610	.	white
pct75.95	−0.900	0.368	.	white	−0.260	0.795	.	white	−0.900	0.368	.	white	0.450	0.653	.	white
pct50.75	−1.160	0.246	.	white	−0.160	0.873	.	white	−1.160	0.246	.	white	−0.010	0.992	.	white
pct25.50	1.320	0.187	.	white	0.260	0.795	.	white	1.320	0.187	.	white	−0.380	0.704	.	white
pct25	−0.240	0.810	.	white	0.220	0.826	.	white	−0.240	0.810	.	white	−0.310	0.757	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference