Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Testicular_germ_cell_tumor)
rsID	Risk allele	Effect size
rs12699477	C	0.191
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Testicular_germ_cell_tumor)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	65	0.076	0.064	0.008	0.061	0.092
SOUTH	38	0.063	0.064	0.010	0.042	0.084
EAST	89	0.097	0.071	0.008	0.082	0.112
Populations
IBS	54	0.071	0.070	0.010	0.052	0.090
PIR	192	0.083	0.068	0.005	0.073	0.093

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Testicular_germ_cell_tumor)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	54	192	0.2410	ns	1.000	ns
IBS	WEST	54	65	0.6520	ns	1.000	ns
IBS	SOUTH	54	38	0.5830	ns	1.000	ns
IBS	EAST	54	89	0.0284	*	0.284	ns
WEST	SOUTH	65	38	0.3300	ns	1.000	ns
WEST	EAST	65	89	0.0700	ns	0.700	ns
SOUTH	EAST	38	89	0.0109	*	0.109	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Testicular_germ_cell_tumor)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white
pct75.95	−0.830	0.407	.	white	−0.430	0.667	.	white	−0.830	0.407	.	white	1.560	0.119	.	white
pct50.75	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white
pct25.50	0.380	0.704	.	white	1.260	0.208	.	white	0.380	0.704	.	white	0.490	0.624	.	white
pct25	0.200	0.841	.	white	−0.980	0.327	.	white	0.200	0.841	.	white	−1.930	0.054	.
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference