Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Thyroid_volume)
rsID Risk allele Effect size
rs10917468 C 0.419
rs4338740 C 0.372
rs12045440 T 0.322
rs3813579 A 0.278
Effect size: LN(OR)
Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Thyroid_volume)
count mean sd se lower.ci upper.ci
Pyrenean regions
WEST 168 0.127 0.056 0.004 0.119 0.136
SOUTH 83 0.133 0.056 0.006 0.121 0.145
EAST 146 0.135 0.058 0.005 0.126 0.145
Populations
IBS 107 0.139 0.058 0.006 0.128 0.150
PIR 397 0.131 0.057 0.003 0.126 0.137
Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Thyroid_volume)
group1 group2 n1 n2 p p.signif p.adj p.adj.signif
IBS PIR 107 397 0.2070 ns 1.000 ns
IBS WEST 107 168 0.0878 ns 0.878 ns
IBS SOUTH 107 83 0.4640 ns 1.000 ns
IBS EAST 107 146 0.5810 ns 1.000 ns
WEST SOUTH 168 83 0.4370 ns 1.000 ns
WEST EAST 168 146 0.2130 ns 1.000 ns
SOUTH EAST 83 146 0.7890 ns 1.000 ns
* p < .05, ** p < .01, *** p < .001
Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Thyroid_volume)
Percentile rank PIR WEST SOUTH EAST
adj.std.val p.value sig.val adj.std.val p.value sig.val adj.std.val p.value sig.val adj.std.val p.value sig.val
pct95 −0.900 0.368 . white −1.410 0.159 . white −0.900 0.368 . white −0.350 0.726 . white
pct75.95 0.100 0.920 . white 0.070 0.944 . white 0.100 0.920 . white 0.370 0.711 . white
pct50.75 −1.340 0.180 . white −0.730 0.465 . white −1.340 0.180 . white −1.020 0.308 . white
pct25.50 1.080 0.280 . white 0.020 0.984 . white 1.080 0.280 . white 0.310 0.757 . white
pct25 0.620 0.535 . white 1.310 0.190 . white 0.620 0.535 . white 0.590 0.555 . white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference