Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Type_II_diabetes)
rsID	Risk allele	Effect size
rs2292626	C	0.068
rs60780116	T	0.086
rs7224685	T	0.068
rs1061810	A	0.068
rs10146997	G	0.068
rs6918311	A	0.058
rs78761021	G	0.058
rs137848	C	0.051
rs8192675	T	0.051
rs4846569	C	0.062
rs6691335	C	0.094
rs367943	C	0.049
rs1904096	A	0.051
rs10841855	G	0.073
rs6438234	G	0.051
rs989128	G	0.051
rs1625526	A	0.058
rs1019029	G	0.049
rs917195	C	0.073
rs10498828	C	0.051
rs62530366	G	0.049
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Type_II_diabetes)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.032	0.004	0.000	0.031	0.032
SOUTH	83	0.032	0.004	0.000	0.031	0.032
EAST	146	0.032	0.005	0.000	0.031	0.033
Populations
IBS	107	0.031	0.004	0.000	0.031	0.032
PIR	397	0.032	0.004	0.000	0.031	0.032

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Type_II_diabetes)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.390	ns	1	ns
IBS	WEST	107	168	0.595	ns	1	ns
IBS	SOUTH	107	83	0.833	ns	1	ns
IBS	EAST	107	146	0.204	ns	1	ns
WEST	SOUTH	168	83	0.794	ns	1	ns
WEST	EAST	168	146	0.397	ns	1	ns
SOUTH	EAST	83	146	0.341	ns	1	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Type_II_diabetes)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	−1.550	0.121	.	white	−1.440	0.150	.	white	−1.550	0.121	.	white	−0.190	0.849	.	white
pct75.95	0.790	0.430	.	white	1.110	0.267	.	white	0.790	0.430	.	white	1.520	0.129	.	white
pct50.75	0.310	0.757	.	white	0.310	0.757	.	white	0.310	0.757	.	white	0.610	0.542	.	white
pct25.50	0.200	0.841	.	white	0.070	0.944	.	white	0.200	0.841	.	white	−0.360	0.719	.	white
pct25	−0.380	0.704	.	white	−0.620	0.535	.	white	−0.380	0.704	.	white	−1.550	0.121	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference