Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Ulcerative_colitis)
rsID Risk allele Effect size
rs16940186 C 0.445
rs9268853 T 0.315
rs17085007 C 0.315
Effect size: LN(OR)
Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Ulcerative_colitis)
count mean sd se lower.ci upper.ci
Pyrenean regions
WEST 168 0.115 0.066 0.005 0.105 0.125
SOUTH 83 0.113 0.062 0.007 0.099 0.127
EAST 146 0.109 0.061 0.005 0.099 0.119
Populations
IBS 107 0.129 0.063 0.006 0.117 0.141
PIR 397 0.112 0.063 0.003 0.106 0.119
Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Ulcerative_colitis)
group1 group2 n1 n2 p p.signif p.adj p.adj.signif
IBS PIR 107 397 0.0183 * 0.183 ns
IBS WEST 107 168 0.0849 ns 0.849 ns
IBS SOUTH 107 83 0.0895 ns 0.895 ns
IBS EAST 107 146 0.0140 * 0.140 ns
WEST SOUTH 168 83 0.7930 ns 1.000 ns
WEST EAST 168 146 0.3770 ns 1.000 ns
SOUTH EAST 83 146 0.6380 ns 1.000 ns
* p < .05, ** p < .01, *** p < .001
Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Ulcerative_colitis)
Percentile rank PIR WEST SOUTH EAST
adj.std.val p.value sig.val adj.std.val p.value sig.val adj.std.val p.value sig.val adj.std.val p.value sig.val
pct95 0.810 0.418 . white 0.880 0.379 . white 0.810 0.418 . white 0.710 0.478 . white
pct75.95 −1.950 0.051 . −1.070 0.285 . white −1.950 0.051 . −2.390 0.017 *
pct50.75 −1.240 0.215 . white −0.010 0.992 . white −1.240 0.215 . white −1.020 0.308 . white
pct25.50 1.160 0.246 . white −0.610 0.542 . white 1.160 0.246 . white 0.640 0.522 . white
pct25 1.540 0.124 . white 1.410 0.159 . white 1.540 0.124 . white 2.210 0.027 *
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference