rsID	Risk allele	Effect size
Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Urate_levels)
rs13129697	TRUE	0.419
Effect size: LN(OR)

	count	mean	sd	se	lower.ci	upper.ci
Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Urate_levels)
Pyrenean regions
WEST	168	0.313	0.121	0.009	0.295	0.331
SOUTH	83	0.300	0.140	0.015	0.270	0.331
EAST	146	0.291	0.131	0.011	0.270	0.313
Populations
IBS	107	0.300	0.132	0.013	0.274	0.325
PIR	397	0.302	0.129	0.006	0.290	0.315

group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Urate_levels)
IBS	PIR	107	397	0.842	ns	1	ns
IBS	WEST	107	168	0.401	ns	1	ns
IBS	SOUTH	107	83	0.966	ns	1	ns
IBS	EAST	107	146	0.615	ns	1	ns
WEST	SOUTH	168	83	0.467	ns	1	ns
WEST	EAST	168	146	0.138	ns	1	ns
SOUTH	EAST	83	146	0.610	ns	1	ns
* p < .05, p < .01, * p < .001

Percentile rank	PIR				WEST				SOUTH				EAST
Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Urate_levels)
Percentile rank	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white
pct75.95	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white
pct50.75	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white
pct25.50	0.350	0.726	.	white	0.500	0.617	.	white	0.350	0.726	.	white	−0.610	0.542	.	white
pct25	−0.350	0.726	.	white	−0.500	0.617	.	white	−0.350	0.726	.	white	0.610	0.542	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, p < .01, * p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference