Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Uterine_fibroids)
rsID	Risk allele	Effect size
rs7913069	T	0.385
rs12484776	G	0.207
rs2280543	C	0.329
rs2172873	A	0.166
rs991964	T	0.140
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Uterine_fibroids)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	103	0.087	0.021	0.002	0.083	0.091
SOUTH	45	0.091	0.015	0.002	0.087	0.096
EAST	57	0.092	0.019	0.002	0.087	0.097
Populations
IBS	53	0.088	0.019	0.003	0.083	0.094
PIR	205	0.089	0.019	0.001	0.087	0.092

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Uterine_fibroids)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	53	205	0.6910	ns	1.000	ns
IBS	WEST	53	103	0.6920	ns	1.000	ns
IBS	SOUTH	53	45	0.4540	ns	1.000	ns
IBS	EAST	53	57	0.2460	ns	1.000	ns
WEST	SOUTH	103	45	0.2220	ns	1.000	ns
WEST	EAST	103	57	0.0812	ns	0.812	ns
SOUTH	EAST	45	57	0.7260	ns	1.000	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Uterine_fibroids)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	−0.440	0.660	.	white	0.550	0.582	.	white	−0.440	0.660	.	white	−0.070	0.944	.	white
pct75.95	−0.320	0.749	.	white	−0.870	0.384	.	white	−0.320	0.749	.	white	1.300	0.194	.	white
pct50.75	1.860	0.063	.	white	0.360	0.719	.	white	1.860	0.063	.	white	0.820	0.412	.	white
pct25.50	−1.070	0.285	.	white	−0.470	0.638	.	white	−1.070	0.285	.	white	−0.750	0.453	.	white
pct25	−0.750	0.453	.	white	0.270	0.787	.	white	−0.750	0.453	.	white	−1.280	0.201	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference