rsID	Risk allele	Effect size
Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Venous_thromboembolism)
rs4253417	C	0.239
rs2066865	A	0.215
rs78707713	T	0.270
rs4524	T	0.182
rs1799963	A	0.829
rs4602861	A	0.182
Effect size: LN(OR)

	count	mean	sd	se	lower.ci	upper.ci
Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Venous_thromboembolism)
Pyrenean regions
WEST	168	0.109	0.027	0.002	0.105	0.113
SOUTH	83	0.104	0.029	0.003	0.098	0.110
EAST	146	0.114	0.028	0.002	0.109	0.119
Populations
IBS	107	0.105	0.026	0.002	0.100	0.110
PIR	397	0.110	0.028	0.001	0.107	0.113

group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Venous_thromboembolism)
IBS	PIR	107	397	0.11400	ns	1.0000	ns
IBS	WEST	107	168	0.26300	ns	1.0000	ns
IBS	SOUTH	107	83	0.81600	ns	1.0000	ns
IBS	EAST	107	146	0.00989	**	0.0989	ns
WEST	SOUTH	168	83	0.19900	ns	1.0000	ns
WEST	EAST	168	146	0.09250	ns	0.9250	ns
SOUTH	EAST	83	146	0.00840	**	0.0840	ns
* p < .05, p < .01, * p < .001

Percentile rank	PIR				WEST				SOUTH				EAST
Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Venous_thromboembolism)
Percentile rank	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	1.660	0.097	.	white	1.910	0.056	.	white	1.660	0.097	.	white	2.110	0.035	*
pct75.95	−1.000	0.317	.	white	−0.500	0.617	.	white	−1.000	0.317	.	white	0.540	0.589	.	white
pct50.75	−1.280	0.201	.	white	0.180	0.857	.	white	−1.280	0.201	.	white	0.160	0.873	.	white
pct25.50	0.990	0.322	.	white	−0.010	0.992	.	white	0.990	0.322	.	white	−0.180	0.857	.	white
pct25	0.460	0.646	.	white	−0.570	0.569	.	white	0.460	0.646	.	white	−1.380	0.168	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, p < .01, * p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference