Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Vitiligo)
rsID	Risk allele	Effect size
rs3806156	T	0.351
rs1393350	G	0.425
rs229527	A	0.322
rs11203203	A	0.239
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Vitiligo)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.183	0.056	0.004	0.174	0.191
SOUTH	83	0.178	0.057	0.006	0.166	0.190
EAST	146	0.169	0.061	0.005	0.159	0.179
Populations
IBS	107	0.167	0.060	0.006	0.156	0.179
PIR	397	0.177	0.058	0.003	0.171	0.182

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Vitiligo)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.1420	ns	1.000	ns
IBS	WEST	107	168	0.0326	*	0.326	ns
IBS	SOUTH	107	83	0.2010	ns	1.000	ns
IBS	EAST	107	146	0.8480	ns	1.000	ns
WEST	SOUTH	168	83	0.5620	ns	1.000	ns
WEST	EAST	168	146	0.0340	*	0.340	ns
SOUTH	EAST	83	146	0.2370	ns	1.000	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Vitiligo)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	0.750	0.453	.	white	1.040	0.298	.	white	0.750	0.453	.	white	0.450	0.653	.	white
pct75.95	−0.270	0.787	.	white	1.140	0.254	.	white	−0.270	0.787	.	white	−0.180	0.857	.	white
pct50.75	0.810	0.418	.	white	0.680	0.497	.	white	0.810	0.418	.	white	−0.190	0.849	.	white
pct25.50	1.200	0.230	.	white	0.260	0.795	.	white	1.200	0.230	.	white	0.410	0.682	.	white
pct25	−2.070	0.038	*		−2.450	0.014	*		−2.070	0.038	*		−0.200	0.841	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference