Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Wilms_tumor)
rsID	Risk allele	Effect size
rs3755132	G	0.372
rs2283873	A	0.718
rs1027643	T	0.358
rs5955543	G	0.971
rs2495478	A	0.336
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Wilms_tumor)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.023	0.035	0.003	0.018	0.029
SOUTH	83	0.023	0.032	0.004	0.016	0.030
EAST	146	0.021	0.029	0.002	0.016	0.026
Populations
IBS	107	0.032	0.039	0.004	0.024	0.040
PIR	397	0.022	0.032	0.002	0.019	0.026

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Wilms_tumor)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.00788	**	0.0788	ns
IBS	WEST	107	168	0.03780	*	0.3780	ns
IBS	SOUTH	107	83	0.05410	ns	0.5410	ns
IBS	EAST	107	146	0.00918	**	0.0918	ns
WEST	SOUTH	168	83	0.85400	ns	1.0000	ns
WEST	EAST	168	146	0.50800	ns	1.0000	ns
SOUTH	EAST	83	146	0.71500	ns	1.0000	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Wilms_tumor)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	−1.130	0.258	.	white	−1.180	0.238	.	white	−1.130	0.258	.	white	−2.090	0.037	*
pct75.95	−0.740	0.459	.	white	−0.430	0.667	.	white	−0.740	0.459	.	white	−0.230	0.818	.	white
pct50.75	−0.170	0.865	.	white	−1.000	0.317	.	white	−0.170	0.865	.	white	−0.590	0.555	.	white
pct25.50	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white
pct25	1.260	0.208	.	white	1.680	0.093	.	white	1.260	0.208	.	white	1.520	0.129	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference